丹曲林(Dantrolene)

商品名(trade name)
藥理作用(Pharmacological Effects)	＊muscle relaxant that acts by abolishing excitation-contraction coupling in muscle cells, probably by action on the ryanodine receptor ＊inhibit RYR of Excitation-Contraction Coupling, and cause calcium ion cannot release. RYR is on Sarcoplasmic reticulum：詳細說明當動作電位到達肌細胞時，會造成T小管上的DHPR與SR上的RYR發生構型上的變化，使得鈣離子從肌漿質網釋出，造成肌肉收縮。而Dantrlene則會與骨骼肌上的RYR1結合（非平滑肌RYR2或心肌，具選擇性），讓鈣離子釋放減少造成骨骼肌的舒張。 參見：興奮收縮聯合作用(Excitation-Contraction Coupling, EC coupling) 資料來源：farmacol
用量與用法(Dosage and Usage)	]per os is common, from low dose to high dose 25mg~100mg/day. This drug can be use bid or qid ]IV infusion ]IV bolus
適應症(Indications)	{惡性高溫臨床症狀(clinical signs of malignant hyperthermia)：同時施打全身麻醉劑（halothane）與骨骼肌鬆弛劑（SCh）後，會造成SR上的鈣離子通道持續開啟，使肌肉過度收縮 參見：痙攣(spasticity)
副作用(Side effect)	}some CNS infection }Lethargic }dizziness }weakness }liver disease
禁忌/交互作用(Contraindications / interaction)

▼神經傳導(Nerve conduction) 顯示/隱藏(show/hide)

▼肌肉簡介(muscle introduction) 顯示/隱藏(show/hide)