細胞激素受器(Cytokine receptor)

細胞激素受器是和細胞激素節的東西
在最近幾年,細胞激素受器的研究已經超越細胞激素本身,主要是因為她們扮演重要的角色以及缺乏細胞激素受器會造成某些免疫缺陷,另外因為細胞激素的pleiotropy (基因多效性)、redundancy(基因重複性),藉由細胞激素受器會比較有實用價值
TypeExamplesStructureMechanism
type I cytokine receptor=Hematopoietin Certain conserved motifs in their extracellular amino-acid domain. Connected to Janus kinase (JAK) family of tyrosine kinasesJAK phosphorylate and activate downstream proteins involved in their signal transduction pathways
type II cytokine receptor=Interferon
Many members of theimmunoglobulin superfamily=Interleukin-1 family Share structural homology with immunoglobulins (antibodies), cell adhesion molecules, and even some cytokines.
Tumor necrosis factor receptor family cysteine-rich common extracellular binding domain
chemokine receptors Seven transmembrane helixG protein-coupled
TGF beta receptors
資料來源:維基百科
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