轉錄因子(Transcription factor)

真核生物(eukaryote)特有
一、一般轉錄因子
轉錄因子
功能
RNA polymerase II
催化RNA合成。核醣核酸聚合酶II((RNA聚合酶II/RNA Polymerase II)也是一種轉錄因子，它不一定是在最後才結合到複合體上。完成的複合體稱轉錄複合體(Transcription complex)，到達此階段才能開始轉錄。
TBP
(TATA結合蛋白)
特定的辨識出TATA box
TFIIA
穩定TFIIB和TBP與啟動子的結合
TFIIB
與TBP接合，吸引(recruits)RNA聚合酶-TFIIF聚合體
TFIID
與正負向調控蛋白交互作用，TFIID率先接上TATA序列(TATA box)，隨後其他轉錄因子才接上。TFIID為第一轉錄因子
TFIIE
吸引(recruits)TFIIH，為ATPase且具解旋酶(helicase)活性
TFIIF
緊密的與RNA聚合酶II結合。與TFIIB結合並避免RNA聚合酶與非特定DNA序列結合。
TFIIH
於啟動子鬆開DNA。磷酸化RNA聚合酶。吸引核苷酸切除修復聚合體(nucleotide-excision repair complex)。

資料來源：hindawi
二、調節型轉錄因子(Regulatory transcription factor)
1.有增強子(Enhancer)、silencer，可以改變promoter活性   activator或repressor

註：可被蛋白質結合上去做轉錄調控的DNA部位稱作Cis element，例如operator、promotor、enhancer、silencer；而那些可以結合DNA去做轉錄調控的蛋白質稱為Trans factor，像是repressor、activator

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6 意見:

  1. Unknown2014年6月4日 晚上9:25

    我不太認同"TFIID(不重要)"這個部分，TFIID含有TBP可以辨識DNA上TATA BOX的位置，使RNAP II上到正確的位置進行轉錄，我認為這個滿重要的阿~

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  2. Unknown2017年7月10日 中午12:42

    The quantity transcriptionists make varies wildly. You can anticipate entry level healthcare transcription jobs to pay about five cents per line. According to the most recent Bureau of Labor statistics for 2010, mt's make (on average) $32,000 per year which is about $15.00 per hour. Honestly, I find that tough to think. What that Bureau of Labor investigation does not take into account is the expertise essential to make that income and the time involved every day to do that work. Americans look at that figure and see it as the outcome of a 40-hour operating week. Let me inform you straight up and honestly, that figure does NOT reflect 40 hours a week, eight hours a day. http://www.protranscriptionservice.com/transcription-services.html It really is a lot more like 10-12 hours a day, 60+ hours per week of intense focus and determined work. If you have a dictator who is plain spoken and effortless to comprehend, you may well make that much income with less than 60 hours per week.

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  3. Unknown2017年7月10日 中午12:44

    Transcription Service

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  4. 匿名2022年4月7日 晚上8:08

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